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Create molecules that color sugar.

Keywords: analytical reagents, molecular recognition, supramolecular chemistry, metal complexes, nanoparticles, luminescence, dyes

Various types of sugars exist within living organisms. Each of these plays an essential role in maintaining life and is constantly circulating within the body. Therefore, an imbalance of sugars in the body directly leads to serious diseases that threaten us today (e.g., diabetes). In other words, the development of technology to measure sugar levels is crucial for the early detection of bodily disorders. To develop such technology, I am designing "analytical reagents," which are molecules that glow when they bind to sugars. In my research, I am developing analytical reagents with a simple structure and excellent detection capabilities by using various frameworks (organic dyes, metal complexes, supramolecular complexes, nanoparticles, etc.) as a foundation (Figure 1). So far, I have successfully developed a supramolecular complex-type analytical reagent that specifically fluoresces for D-glucose (blood sugar) among the numerous sugars (Figure 2). I believe that this technology will lead to the development of a diagnostic system for the early detection of diabetes.

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